Studying Causes of Alzheimer's Disease
The Department of Biological Chemistry
“One of our most exciting projects is to use crosslinking coupled with mass spectrometry to study the structures of filaments and proteins in brain tissue. Disruption of these structures is one of the causes of neurodegenerative diseases such as Alzheimer’s. These findings can only be realized through the very high sensitivity of our mass spectrometers and their high throughput capacities. In another project that uses this shared equipment, we are trying to find how a certain protein is structured with other proteins to exert its toxic effect in the FSHD muscle degeneration disease.”
- Dr. Nir Kalisman